What are the signs and symptoms of symmetric peripheral gangrene?

Updated: Jul 27, 2020
  • Author: Cassius Iyad Ochoa Chaar, MD, MS, FACS; Chief Editor: Vincent Lopez Rowe, MD  more...
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Another condition that might present with limb ischemia in the setting of patent arterial supply is symmetric peripheral gangrene, a condition in which microvascular occlusion of venules and capillaries occurs in the setting of severe systemic infection and widespread inflammation. [11] In this condition, patients have systemic tissue ischemia and coagulopathy, resulting in autoamputation of distal digits in combination with disseminated intravascular coagulation (DIC). There is cyanotic discoloration of the tips of all four limbs (ie, acral cyanosis), as well as patches of cyanosis throughout the body (ie, nonacral cyanosis or purpura fulminans).

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