What are the key components in the pathogenesis of cholesterol embolism syndrome?

Updated: Oct 25, 2019
  • Author: Lisa Kirkland, MD, FACP, FCCM, MSHA; Chief Editor: Vincent Lopez Rowe, MD  more...
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Answer

Key components of CES include the following:

  • Proximal large-caliber arterial plaque
  • Plaque rupture with embolization of debris
  • Mechanical occlusion of small arteries
  • Intense foreign-body inflammation
  • End-organ damage from mechanical obstruction
  • Inflammatory vascular changes

Any organ system, with the exception of the lungs, may be directly affected. CES has two mechanisms of action.


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