What is the role of skin biopsy in the workup of diabetic foot ulcers?

Updated: Oct 15, 2020
  • Author: Tanzim Khan, DPM; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

In the setting of a nonhealing, chronic wound, it is advisable to send a skin biopsy for histopathologic examination to rule out malignancy. Skin biopsies may also be beneficial to rule out other differential diagnoses such as calciphylaxis, vasculitis, and venous stasis. The wound biopsy can be incisional, excisional, or performed via punch biopsy.


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