Which medications in the drug class Anticoagulants, Hematologic are used in the treatment of Peripheral Arterial Occlusive Disease?

Updated: Sep 12, 2019
  • Author: Josefina A Dominguez, MD; Chief Editor: Vincent Lopez Rowe, MD  more...
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Answer

Anticoagulants, Hematologic

Anticoagulants decrease microthrombus formation. Reversible elevation of hepatic transaminase levels occurs occasionally. Heparin-associated thrombocytopenia has been observed with low-molecular-weight heparin (LMWH).

Enoxaparin (Lovenox)

Enoxaparin enhances the inhibition of factor Xa and thrombin by increasing antithrombin III activity. It also slightly affects thrombin and clotting time and preferentially increases the inhibition of factor Xa.

This agent has a wide therapeutic window; the prophylactic dose is not adjusted based on the patient's weight. Enoxaparin is safer and more effective than unfractionated heparin for prophylaxis of venous thromboembolism. The average duration of treatment is 7-14 days.

Dalteparin (Fragmin)

Dalteparin is an LMWH with antithrombotic properties. It enhances the inhibition of factor Xa and thrombin by increasing antithrombin. It has a minimal effect on activated partial thromboplastin time (aPTT).

Tinzaparin

Tinzaparin is an LMWH with antithrombotic properties. It enhances the inhibition of factor Xa and thrombin by increasing antithrombin. It has a minimal effect on aPTT.


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