What is the role of lab testing in the workup of thromboangiitis obliterans (TAO) (Buerger disease)?

Updated: Jul 27, 2020
  • Author: Naiem Nassiri, MD; Chief Editor: Vincent Lopez Rowe, MD  more...
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Answer

The primary goal of a laboratory workup in patients thought to have the disease is to exclude other disease processes in the differential diagnosis. Tests often used as markers for the diagnosis of systemic vasculitis, such as the acute-phase reactants, yield negative results in patients with TAO. Tests commonly ordered include the following:

  • Complete blood count (CBC) with differential

  • Liver function tests

  • Renal function tests

  • Urinalysis

  • Glucose (fasting)

  • Erythrocyte sedimentation rate (ESR)

  • C-reactive protein (CRP)

  • Antinuclear antibody (ANA)

  • Rheumatoid factor (RF)

  • Complement

  • Anticentromere antibody

  • Scl-70 antibody

  • Antiphospholipid antibodies


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