What is the role of trospium chloride (Sanctura) in the treatment of overactive bladder (OAB) in children?

Updated: Apr 01, 2019
  • Author: Pamela I Ellsworth, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Trospium chloride (Sanctura), another agent used in adults, has been studied in a small series of children, with dosages ranging from 10 to 25 mg/d, divided into 2 doses daily; overall, 32% of the subjects had an excellent response to the drug, 42% a good response, and 8% a fair response. [34]  Detrusor overactivity resolved completely in 35%. Trospium is currently approved for use in the United States for adults in a dose of 20 mg orally twice daily. No dosing guidelines or safety and efficacy information are available regarding its use in children.

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