What is the role of anticholinergics in the treatment of overactive bladder (OAB) in children?

Updated: Apr 01, 2019
  • Author: Pamela I Ellsworth, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

The use of anticholinergic therapy in the management of OAB is predicated on the concept that parasympathetic-mediated stimulation of muscarinic receptors (M3 primarily) in the bladder leads to detrusor overactivity. Anticholinergic/antimuscarinic agents have been demonstrated to increase bladder capacity, to improve bladder compliance, and to decrease uninhibited detrusor contractions.

Anticholinergic agents are often used in children with OAB when behavioral therapy has failed or as an adjunct to behavioral therapy. Despite the frequent use of anticholinergic agents in children with OAB, few randomized studies have assessed the safety and efficacy of these drugs in this setting.


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