What is the role of trimethoprim/sulfamethoxazole (TMP/SMX) for the treatment of chronic bacterial prostatitis (CBP)?

Updated: Jan 15, 2019
  • Author: Samantha D Kraemer, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Trimethoprim/sulfamethoxazole (TMP/SMX) or even trimethoprim alone were widely used in the 1970s to 1990s. Eradication rates ranged from 0% to 67%, with most studies reporting rates of 30%-50% with a 4- to 6-week course of treatment. Longer duration of therapy, around 90 days, provides best clinical results. TMP/SMX does have good penetration into the prostate and activity against most relevant pathogens but resistance rates are high. It does not have activity against Pseudomonas,Chlamydia, or gonococci. Overall, TMP/SMX is less effective for bacterial eradication than fluoroquinolones. [1]

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