What are the eradication rates among fluoroquinolones for the treatment of chronic bacterial prostatitis (CBP)?

Updated: Jan 15, 2019
  • Author: Samantha D Kraemer, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Reported microbiological eradication rates are 40%-70% for ciprofloxacin and 75% for levofloxacin. One comparative study of patients with CBP concluded that levofloxacin 500 mg once daily is as effective as ciprofloxacin 500 mg twice daily for 4 weeks [38] A similar study found that compared with ciprofloxacin, levofloxacin produced higher rates of bacterial clearance and clinical improvement, as well as lower rates of microbiological recurrence. [39]

In contrast, a systematic review of 18 studies reported no significant differences in clinical improvement, microbiological eradication, or rate of adverse effects among oral fluoroquinolones, including ciprofloxacin, levofloxacin, lomefloxacin, ofloxacin, and prulifloxacin. [40] The optimal duration of fluoroquinolone treatment for CBP caused by traditional organisms is not well studied and more research is needed optimize doses and lengths of antibiotics being prescribed.


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