What is the role of genomic assays in prostate cancer diagnosis and screening?

Updated: Jan 15, 2019
  • Author: Lanna Cheuck, DO; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Answer

In a review highlighting advantages and limitations of genomic testing, Falzarano et al note the vast variety of new testing available for aiding in diagnosis and risk stratification for prostate cancer. [38] In addition to the Prolaris/CCP score and Decipher, other genomic assays mentioned in the review include the following:

  • Confirm MDx
  • PCMT
  • Oncotype DX
  • Promark

Advantages of Confirm MDx and PCMT include a high negative predictive value (NPV), which reduces the need for repeat biopsies. [38] Limitations of Confirm MDx and PCMT are their inability to distinguish aggressive from indolent disease, which is a strength of the CCP score and Oncotype DX. [38] As described above, Decipher is unique in that it is a predictor of metastatic disease after RP. [38]


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