What is the range of Gleason scores for prostate cancer?

Updated: Jan 14, 2019
  • Author: Lanna Cheuck, DO; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Answer

Gleason scores range as follows:

  • Score of 2-4 - Considered low grade or well differentiated
  • Score of 5-7 - Considered moderate grade or moderately differentiated
  • Score of 8-10 - Considered high grade or poorly differentiated

Although the change in glandular architecture represented by the Gleason score is currently the most widely used and correlative histologic parameter, it is not the only histologic change that can be observed in prostate cancers. Indeed, notable changes in cell and nuclear morphology, neuroendocrine differentiation, and vascularity can be observed and may have great prognostic significance.


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