What is the role of the Prostate Health Index (PHI) test in prostate cancer screening?

Updated: Jan 14, 2019
  • Author: Lanna Cheuck, DO; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Answer

The Prostate Health Index (PHI) test is a diagnostic blood test that combines free and total PSA and the (-2) pro-PSA isoform (p2PSA). The PHI test is intended to reduce the number of unnecessary prostate biopsies in PSA-tested men. In prospective multicenter studies, the PHI test has outperformed free and total PSA for detection of prostate cancer and has improved prediction of clinically significant prostate cancer in men with a PSA of 2 or 4 ng/mL to 10 ng/mL. [17]


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