Which prostate-specific antigen (PSA) levels suggest prostate cancer?

Updated: Jan 14, 2019
  • Author: Lanna Cheuck, DO; Chief Editor: Edward David Kim, MD, FACS  more...
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PSA is a single-chain glycoprotein that has chymotrypsinlike properties. The upper limit of normal for PSA is 4ng/mL. Some advocate age-related cutoffs, such as 2.5ng/mL for the fifth decade of life, 3.5ng/mL for the sixth decade of life, and 4.5ng/mL for the seventh decade of life. Others advocate race-specific reference ranges. Using data from screening studies, some have advocated upper limits of normal of 2.5ng/mL instead of 4ng/mL.

If the physician believes that an elevated PSA level may be due to infection, 4-6 weeks of antibiotics are provided, and then the PSA level is rechecked.

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