What is the efficacy of combined external beam radiotherapy (EBRT) and brachytherapy for the treatment of prostate cancer?

Updated: Nov 29, 2018
  • Author: Isamettin Andrew Aral, MD, MS; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Answer

A large-scale comprehensive review of the literature by the Prostate Cancer Results Study Group, which compared risk-stratified patients by treatment option and included long-term follow-up, came to the following conclusions [3] :

  • In terms of biochemical-free progression, brachytherapy alone provides superior outcome in patients with low-risk disease

  • For intermediate-risk disease, the combination of EBRT and brachytherapy appears equivalent to brachytherapy alone

  • For high-risk patients, combination therapies involving EBRT and brachytherapy plus or minus androgen deprivation therapy appear superior to more localized treatments such as seed implant alone, surgery alone, or EBRT


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