What are the possible hormonal complications of conventional external beam radiotherapy (EBRT) for prostate cancer?

Updated: Nov 29, 2018
  • Author: Isamettin Andrew Aral, MD, MS; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

A study by Planas et al indicated that in the treatment of localized prostate cancer, EBRT has a greater effect on the hypothalamic-pituitary axis than does radical prostatectomy. The investigators found that at 3 months posttreatment, patients who underwent EBRT had significantly higher luteinizing and follicle-stimulating hormone levels and significantly lower total and free testosterone concentrations than did radical prostatectomy patients. At 12 months posttreatment, EBRT patients still demonstrated significantly higher follicle-stimulating hormone levels and significantly lower total testosterone levels than did the other patients. [19]


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