What is the role of intermittent androgen therapy in the treatment of metastatic and advanced prostate cancer?

Updated: Dec 29, 2020
  • Author: Martha K Terris, MD, FACS; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Answer

Intermittent androgen suppression is a well-established treatment offered to patients with advanced prostate cancer; however, it is not considered the standard of care. [26, 27] Some indications for androgen-withdrawal therapy include newly diagnosed metastatic disease, localized disease with high risk of systemic relapse, prostate-specific antigen (PSA) level rise during treatment, lack of tolerance for side effects, and biochemical failure after local therapy.

Intermittent androgen suppression may delay androgen-independent cancer and increase quality of life (ie, fewer issues regarding potency and libido). Ongoing research is investigating the utility of intermittent treatment.


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