What are the surrogate endpoints for prostate cancer–specific survival at 10 years?

Updated: Dec 29, 2020
  • Author: Martha K Terris, MD, FACS; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Answer

Denham et al reported that the PSA doubling time and the time to biochemical failure can provide useful surrogate endpoints for prostate cancer–specific mortality, potentially meaning that the follow-up period in clinical trials can be significantly reduced. However, further studies are still needed. [24]

In a study, based on an evaluation of data from the Radiation Therapy and Oncology Group 92-02 randomized trial, Ray et al determined that distant metastasis and general failure of clinical treatment at 3 years may be candidates as surrogate endpoints for prostate cancer–specific survival at 10 years, potentially shortening the duration of clinical trials for prostate cancer. However, the investigators concluded that these endpoints still need to be validated in other datasets. [25]


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