Which histologic findings are characteristic of metastatic and advanced prostate cancer?

Updated: Dec 29, 2020
  • Author: Martha K Terris, MD, FACS; Chief Editor: Edward David Kim, MD, FACS  more...
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Currently, the Gleason grading system is the most common classification used that helps to determine the histologic characteristics of prostate cancer. [12] A grade of 1-5 is assigned to the glandular architecture of the tumor. The sum of the most predominant grade and the second most common histologic pattern determines the Gleason score. Patients with a Gleason score of 6 or higher are likely to progress to advanced cancer (if they have not already done so), as are patients with a prostate-specific antigen (PSA) value of 10ng/mL or higher.

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