What are the signs and symptoms of metastatic and advanced prostate cancer?

Updated: Dec 29, 2020
  • Author: Martha K Terris, MD, FACS; Chief Editor: Edward David Kim, MD, FACS  more...
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Advanced prostate cancer results from any combination of lymphatic, blood, or contiguous local spread. Manifestations of metastatic and advanced disease may include the following:

  • Anemia
  • Bone marrow suppression
  • Weight loss
  • Pathologic fractures
  • Spinal cord compression
  • Pain
  • Hematuria
  • Ureteral and/or bladder outlet obstruction
  • Urinary retention
  • Chronic renal failure
  • Urinary incontinence
  • Symptoms related to bony or soft-tissue metastases

Treatment-related symptoms, such as rectal bleeding, gross hematuria, and urethrorectal fistula, which are sometimes associated with radiation therapy, should also be kept in mind.

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