What is the role of imipramine (Tofranil) in the treatment of neurogenic bladder?

Updated: Dec 06, 2018
  • Author: Bradley C Gill, MD, MS; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Answer

Imipramine is a typical tricyclic antidepressant. It facilitates urine storage by decreasing bladder contractility and increasing outlet resistance. It has alpha-adrenergic effect on the bladder neck and antispasmodic effect on detrusor muscle. Imipramine hydrochloride has a local anesthetic effect on bladder mucosa.


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