What is the role of tricyclic antidepressants in the treatment of neurogenic bladder?

Updated: Dec 24, 2020
  • Author: Bradley C Gill, MD, MS; Chief Editor: Edward David Kim, MD, FACS  more...
  • Print


Treatment of bladder dysfunction is an off-label use of tricyclic antidepressants. These drugs function to increase norepinephrine and serotonin levels. In addition, they exhibit anticholinergic and direct muscle relaxant effects on the urinary bladder.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!