What is the role of darifenacin (Enablex) in the treatment of neurogenic bladder?

Updated: Dec 06, 2018
  • Author: Bradley C Gill, MD, MS; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Answer

Darifenacin is an extended-release product that elicits competitive muscarinic receptor antagonistic activity. It reduces bladder smooth muscle contractions. It has a high affinity for M3 receptors involved in bladder and gastrointestinal (GI) smooth muscle contraction, saliva production, and iris sphincter function. Darifenacin is indicated for overactive bladder with symptoms of urge incontinence, urgency, and frequency. The product should be swallowed whole; do not chew, divide, or crush.


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