What is the role of combination therapy in the treatment of neurogenic bladder?

Updated: Dec 06, 2018
  • Author: Bradley C Gill, MD, MS; Chief Editor: Edward David Kim, MD, FACS  more...
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When a single drug treatment does not work, combination therapy may be used. Generally, agents with different mechanisms of action must be combined in order to improve urge incontinence; for instance, the combination of a beta-3 agonist with an anticholinerigic can be used to treate detrusor overactivity.  Together, these drugs produces a synergistic effect to relax the unstable bladder to hold in urine and prevent urge incontinence. However, anticholinergic adverse effects may be additive because both drugs have similar adverse reactions.

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