Which factors are associated with poor prognosis of urothelial tumors of the renal pelvis and ureters?

Updated: Aug 07, 2020
  • Author: Kyle A Richards, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Answer

A history of bladder cancer and a delay to definitive therapy are associated with worse outcomes. Tumor characteristics that predict worse outcomes include the following [10, 75] :

  • Higher pathologic stage
  • Higher pathologic grade
  • Presence of carcinoma in situ
  • Lymph node invasion
  • Lymphovascular invasion
  • Tumor multifocality
  • Sessile growth pattern
  • Larger tumor size
  • Tumor necrosis
  • Positive surgical margins

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