Which medications in the drug class Alpha-Adrenergic Agonists are used in the treatment of Urinary Incontinence?

Updated: Sep 23, 2019
  • Author: Sandip P Vasavada, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Alpha-Adrenergic Agonists

The bladder neck contains a high concentration of receptors that are sensitive to alpha-agonists. Alpha-agonists increase bladder outlet resistance by contracting the bladder neck. These agents are beneficial in the treatment of mild to moderately severe stress incontinence in women.

Midodrine

The active metabolite of midodrine, desglymidodrine, is an alpha1-agonist that may increase bladder outlet resistance.

Pseudoephedrine hydrochloride (Sudafed, Genaphed, SudoGest)

Pseudoephedrine helps stress incontinence. The subjective improvement and cure rates are similar to that of phenylpropanolamine, which was recalled from the US market. Pseudoephedrine stimulates vasoconstriction by directly activating alpha-adrenergic receptors.

Phenylpropanolamine

Recalled from US market. Epinephrine stores are released under phenylpropanolamine stimulation and produce alpha- and beta-adrenergic stimulation. These effects may increase bladder outlet resistance.


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