Which medications in the drug class Alpha-Adrenergic Agonists are used in the treatment of Urinary Incontinence?

Updated: Jan 22, 2021
  • Author: Sandip P Vasavada, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Alpha-Adrenergic Agonists

The bladder neck contains a high concentration of receptors that are sensitive to alpha-agonists. Alpha-agonists increase bladder outlet resistance by contracting the bladder neck. These agents are beneficial in the treatment of mild to moderately severe stress incontinence in women.


The active metabolite of midodrine, desglymidodrine, is an alpha1-agonist that may increase bladder outlet resistance.

Pseudoephedrine hydrochloride (Sudafed, Genaphed, SudoGest)

Pseudoephedrine helps stress incontinence. The subjective improvement and cure rates are similar to that of phenylpropanolamine, which was recalled from the US market. Pseudoephedrine stimulates vasoconstriction by directly activating alpha-adrenergic receptors.

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