What is the role of calcium channel blockers in urinary incontinence treatment?

Updated: Mar 19, 2019
  • Author: Sandip P Vasavada, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

In a small study, verapamil was no more effective than placebo and less effective than oxybutynin. However, verapamil combined with oxybutynin was more effective than oxybutynin alone. Terodiline was once a very popular drug for the treatment of detrusor overactivity in Europe but has since been withdrawn from the market due to a potential for serious adverse cardiac effects.

A small study showed magnesium hydroxide to be beneficial for some patients with sensory urgency and detrusor overactivity. [71] The presumed mechanism of action is through calcium antagonism. More work is needed before this treatment is recommended.


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