In a small study, verapamil was no more effective than placebo and less effective than oxybutynin. However, verapamil combined with oxybutynin was more effective than oxybutynin alone. Terodiline was once a very popular drug for the treatment of detrusor overactivity in Europe but has since been withdrawn from the market due to a potential for serious adverse cardiac effects.
A small study showed magnesium hydroxide to be beneficial for some patients with sensory urgency and detrusor overactivity.  The presumed mechanism of action is through calcium antagonism. More work is needed before this treatment is recommended.