Which paraneoplastic syndromes associated with renal cell carcinoma (RCC) can be ameliorated by radical nephrectomy?

Updated: Feb 05, 2019
  • Author: Richard A Santucci, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Answer

Nephrectomy can ameliorate paraneoplastic syndromes, hemorrhaging, and tumor pain. Paraneoplastic syndromes associated with RCC include the following:

  • Anemia (21-41%)

  • Elevated sedimentation rate (50-60%)

  • Reversible hepatic dysfunction (10-15%)

  • Fever (7-17%)

  • Amyloidosis (3-5%)

  • Neuromyopathy (3%)

  • Hypercalcemia (3-6%)

  • Erythrocytosis (3-4%)

  • Hypertension (22-38%)

  • Elevated human chorionic gonadotropin levels

  • Cushing syndrome

  • Hyperprolactinemia

  • Ectopic insulin and glucagon production

  • Raised alkaline phosphatase levels (10%)

  • Cachexia, weight loss (35%)


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