When is radical nephrectomy indicated?

Updated: Feb 05, 2019
  • Author: Richard A Santucci, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Answer

Radical nephrectomy remains the procedure of choice for surgically resectable lesions. Relapse occurs in 20-30% of patients with completely resected RCC after radical nephrectomy. Radical nephrectomy is also indicated in patients with metastatic disease as part of immunotherapy or the new chemotherapy protocol as a palliative procedure in cases of intractable pain and bleeding. Many cases are now treated with new FDA-approved tyrosine kinase inhibitors as adjuvant therapy. In addition, several new medications are now in phase II and phase III trials for the management of metastatic renal cancer. Results so far have been promising in terms of improving survival and delaying progression.


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