What is the role of phentolamine in the treatment of erectile dysfunction (ED)?

Updated: Aug 08, 2018
  • Author: Edward David Kim, MD, FACS; Chief Editor: Edward David Kim, MD, FACS  more...
  • Print
Answer

Phentolamine is an alpha-receptor blocker that has not been approved by the FDA for the treatment of ED but has undergone limited clinical testing. Two placebo-controlled trials reported effectiveness in 42% and 32% of patients taking 50 mg, compared with 9% and 13% of control subjects, respectively. The erections occurred in 20-30 minutes. The drug was well tolerated, with mild-to-moderate adverse effects (usually headaches or light-headedness) occurring in less than 10% of patients.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!