What is the role of yohimbine in the treatment of erectile dysfunction (ED)?

Updated: Oct 14, 2020
  • Author: Edward David Kim, MD, FACS; Chief Editor: Edward David Kim, MD, FACS  more...
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Yohimbine, a bark extract, has been available for many years. It has both a central and a peripheral effect. Even in properly conducted, well-controlled studies, it is only slightly more effective than placebo, and AUA guidelines do not recommend its use. [1] Nevertheless, there has been a renewed interest in this agent, particularly when it is combined with an oral PDE5 inhibitor. [106] Yohimbine is a safe agent with few known adverse effects. It is administered in a dosage of 5.4 mg (1 tablet) 3 times daily

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