Which medications have been investigated for the treatment of erectile dysfunction (ED)?

Updated: Oct 14, 2020
  • Author: Edward David Kim, MD, FACS; Chief Editor: Edward David Kim, MD, FACS  more...
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Before the advent of oral PDE5 inhibitors, various other oral medications were investigated for treatment of ED, including the following [85] :

  • Adrenergic receptor antagonists (eg, phentolamine, yohimbine, and delequamine)

  • Dopamine receptor antagonists (eg, apomorphine and bromocriptine)

  • Serotoninergic receptor activators (eg, trazodone)

  • Xanthine derivatives (eg, pentoxifylline)

  • Oxytocinergic receptor stimulators (eg, oxytocin)

Although the AUA does not recommend the use of any of these agents, [1]  several are worth reviewing briefly.

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