What is the treatment for medication-related erectile dysfunction?

Updated: Oct 14, 2020
  • Author: Edward David Kim, MD, FACS; Chief Editor: Edward David Kim, MD, FACS  more...
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Hyperprolactinemia from antipsychotic medication, especially risperidone, has been associated with sexual dysfunction. Treatment has included dose reduction, drug holidays, adjunctive medication, and switching to another drug (eg, olanzapine); however, data to support any of those strategies are limited. [75] A small open-label study by Fujioi et al of adjunctive aripiprazole for patients with antipsychotic-induced hyperprolactinemia and sexual dysfunction reported a significant decrease in erectile dysfunction at week 24. [76]

The use of methadone for opioid replacement therapy has been associated with increased rates of ED. [77] Treatment with sustained-release bupropion proved effective in a phase II, randomized, double-blind, parallel-group, placebo-controlled trial involving 80 men with sexual dysfunction that emerged during methadone maintenance therapy. Of the patients receiving bupropion, 58.3% reported that their sexual funcion was "much/very much improved" compared with 27.7% of those receiving placebo. [78]

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