Which medications in the drug class Antineoplastics, Vinca Alkaloid are used in the treatment of Bladder Cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Answer

Antineoplastics, Vinca Alkaloid

Vinca alkaloids act on the M and S phases of mitosis, inhibiting microtubule formation and inhibiting DNA/RNA synthesis.

Vinblastine

A vinca alkaloid with a cytotoxic effect (as a result of causing mitotic arrest), vinblastine binds to a specific site on tubulin, prevents polymerization of tubulin dimers, and inhibits microtubule formation. Although not FDA approved for this indication, vinblastine is often used as a treatment for bladder cancer in combination with a chemotherapy regimen.

Vinblastine is approved for intravenous use only; the FDA has issued a black box warning regarding possible death with intrathecal administration. Vinblastine is a moderate vesicant and extravasation should be avoided.


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