Which medications in the drug class Antineoplastics, Anthracycline are used in the treatment of Bladder Cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Antineoplastics, Anthracycline

Anthracycline antineoplastics inhibit DNA and RNA synthesis by steric obstruction. They intercalate between DNA base pairs and trigger DNA cleavage by topoisomerase II.

Doxorubicin (Adriamycin)

Doxorubicin is an anthracycline antineoplastic that causes DNA strand breakage through effects on topoisomerase II and direct intercalation into DNA, which causes DNA polymerase inhibition. It has a labeled indication for the treatment of bladder cancer. The largest benefit this agent has compared with other intravesical chemotherapeutic agents is its low cost and ability to decrease tumor recurrence.This drug has several black box warnings, including bone marrow suppression, myocardial toxicity, and secondary malignancy.

Valrubicin (Valstar)

Valrubicin is a semisynthetic analog of doxorubicin that inhibits incorporation of nucleosides into nucleic acids. It is indicated for intravesicular treatment of bladder carcinoma in situ (CIS) that is refractory to treatment with bacillus Calmette-Guérin (BCG).

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