Which medications in the drug class Antineoplastics, Antimicrotubular are used in the treatment of Bladder Cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Antineoplastics, Antimicrotubular

These agents prevent cell growth and proliferation. They work by enhancing tubulin dimers, as well as by stabilizing existing microtubules and inhibiting their disassembly.

Docetaxel (Taxotere, Docefrez)

Docetaxel inhibits the depolymerization of tubulin, which inhibits DNA, RNA, and protein synthesis. It can be used for the treatment of bladder cancer, which is an off-label indication. It has several black box warnings, including bone marrow suppression, fluid retention, and hypersensitivity reactions. Its use is not recommended in certain patients with hepatic impairment. Patients receiving docetaxel treatment should be premedicated with corticosteroids the day before administration to help reduce fluid retention and hypersensitivity reactions.

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