What is the role of interferon alpha or gamma in the treatment of bladder cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Answer

Interferon alfa or gamma has been used in the treatment of stages Ta and T1 and CIS urothelial carcinoma, either as single-agent therapy or in combination with BCG. [99] Its role has primarily been in treatment following BCG failure. Early results in nonrandomized, retrospective series have reported a 42% response with tolerable adverse effects after BCG failure. However, no evidence has indicated that retreatment with BCG plus interferon is superior to retreatment with BCG alone.


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