What are EAU recommendations for neoadjuvant therapy in the treatment of bladder cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Answer

Neoadjuvant therapy:

  • Offer neoadjuvant chemotherapy for T2-T4a, cN0M0 bladder cancer.
  • Always use a cisplatin-based combination regimen for neoadjuvant chemotherapy. Do not offer neoadjuvant chemotherapy to patients who are ineligible for cisplatin-based combination chemotherapy.
  • Only offer neoadjuvant immunotherapy to patients within a clinical trial setting.
  • Do not offer preoperative radiotherapy (RT) for operable MIBC since it will only result in down-staging, but will not improve survival.
  • Do not offer preoperative RT when subsequent radical cystectomy with urinary diversion is planned.

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