Which factors affect the sensitivity of cytology in detecting bladder cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Answer

Several other factors affect the sensitivity of cytology, including specimen quality, number of exfoliated cells, and pathologist expertise. However, the overall low sensitivity of cytology is due to its low sensitivity in detecting low-grade bladder tumors. [74]  Urine cytology is associated with a significant false-negative rate, especially for low-grade carcinoma (10-50% accuracy rate). The false-positive rate is 1-12%, although cytology has a 95% accuracy rate for diagnosing high-grade carcinoma and CIS.


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