What are the main differential diagnoses for small cell carcinoma bladder cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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With small cell carcinoma, the main differential diagnoses are high-grade urothelial carcinoma, lymphoma, and sarcoma. Additionally, metastatic small cell carcinoma should be ruled out based on the available clinical information. Because small cell carcinoma of the urinary bladder is often mixed with urothelial carcinoma and because any presence of small cell carcinoma is justifiable to render the diagnosis, it is important to thoroughly examine the tumor tissue.

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