What is the prognosis of squamous cell carcinoma (SCC) bladder cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
  • Print
Answer

Tumor stage, lymph node involvement, and tumor grade have been shown to be of independent prognostic value in SCC. [55, 56] However, pathologic stage is the most important prognostic factor. In one relatively large series of 154 cases, the overall 5-year survival rate was 56% for pT1 and 68% for pT2 tumors. However, the 5-year survival rate for pT3 and pT4 tumors was only 19%. [53]

Several studies have demonstrated grading to be a significant morphologic parameter in SCC. [53] In one series, 5-year survival rates for grade 1, 2, and 3 SCC was 62%, 52%, and 35%, respectively. [53] In the same study of patients undergoing cystectomy, the investigators suggested that a higher number of newly formed blood vessels predicts unfavorable disease outcome.

In SCC, the survival rate appears to be better with radical surgery than with radiation therapy and/or chemotherapy. In locally advanced tumors, however, neoadjuvant radiation improves the outcome. [57] Sex and age have not been prognostically significant in SCC. [53]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!