What are the risk factors for squamous cell carcinoma (SCC) bladder cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Having bladder diverticula may increase an individual’s chance of developing SCC. [34] Rarely, bacillus Calmette-Guerin (BCG) treatment for CIS has been reported to lead to development of SCC. [35] Development of bladder cancer at a younger age has been associated with bladder exstrophy. [36, 37, 38, 39] SCC has also been described in urachal remnants. [40, 41, 42, 43, 44]

Coffee consumption does not increase the risk of developing bladder cancer. Early studies of rodents and a minority of human studies suggested a weak connection between artificial sweeteners (eg, saccharin, cyclamate) and bladder cancer; however, most recent studies show no significant correlation.

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