What are the medical risk factors for bladder cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Several medical risk factors are associated with an increased risk of bladder cancer, including the following:

  • Radiation treatment of the pelvis

  • Chemotherapy with cyclophosphamide - Increases the risk of bladder cancer via exposure to acrolein, a urinary metabolite of cyclophosphamide [27]

  • Spinal cord injuries requiring long-term indwelling catheters - A 16- to 20-fold increase in the risk of developing SCC of the bladder

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