What are the phenotypes of urothelial carcinoma bladder cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Answer

Clinical and pathologic data indicate that at least 3 different phenotypes, as follows, exist in urothelial carcinoma [2, 3] :

  • Low-grade proliferative lesions that develop into non–muscle-invasive tumors; these account for approximately 80% of bladder cancers
  • Highly proliferative invasive tumors with a propensity to metastasize
  • CIS, which can penetrate the lamina propria and eventually progress

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