What are the treatment options for muscle-invasive bladder cancer?

Updated: Feb 23, 2021
  • Author: Kara N Babaian, MD, FACS; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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The treatment of muscle-invasive bladder cancer is as follows:

  • Radical cystoprostatectomy in men
  • Radical cystectomy with anterior pelvic exenteration in women
  • Bilateral pelvic lymphadenectomy (PLND), standard or extended
  • Creation of a urinary diversion (eg, ileal conduit, Indiana pouch, orthotopic bladder substitution)
  • Neoadjuvant chemotherapy - May improve cancer-specific survival

Alternatively, a bladder-sparing approach of TURBT followed by concurrent radiation therapy and systemic chemotherapy (trimodality therapy) may be used.

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