Which alpha-blocking drugs are used in the treatment of benign prostatic hyperplasia (BPH)?

Updated: Feb 19, 2021
  • Author: Levi A Deters, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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The alpha-blocking agents studied in BPH can be subgrouped according to receptor subtype selectivity and the duration of serum elimination half-lives, as follows:

  • Nonselective alpha-blockers - Phenoxybenzamine
  • Selective short-acting alpha-1 blockers - Prazosin, alfuzosin, indoramin
  • Selective long-acting alpha-1 blockers -  Terazosin, doxazosin, slow-release (SR) alfuzosin.
  • Partially subtype (alpha-1a)–selective agents – Tamsulosin (Flomax), silodosin (Rapaflo)

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