Which medications in the drug class Alkalinizing Agents, Oral are used in the treatment of Nephrolithiasis?

Updated: Sep 16, 2021
  • Author: Chirag N Dave, MD; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Alkalinizing Agents, Oral

Oral alkalinizing agents are used for the treatment of metabolic acidosis. They are also employed when long-term maintenance of alkaline urine is desirable.

Potassium citrate (Urocit K)

Potassium citrate is absorbed and metabolized to potassium bicarbonate, thus acting as a systemic alkalizer. Its effects are essentially those of chlorides before absorption and those of bicarbonates subsequently. Oxidation is virtually complete so that < 5% of the potassium citrate is excreted in the urine unchanged. It is highly concentrated and, when administered after meals and before bedtime, allows maintenance of an alkaline urinary pH at all times, usually without necessity of 2 AM dose. In the recommended dosage, it alkalinizes urine without producing systemic alkalosis.

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