Which medications in the drug class Tricyclic antidepressants are used in the treatment of Premature Ejaculation?

Updated: Jan 15, 2019
  • Author: Samuel G Deem, DO; Chief Editor: Edward David Kim, MD, FACS  more...
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Tricyclic antidepressants

Drugs with SSRI-like side effects (eg, delaying sexual climax), such as certain TCAs, can be used to treat premature ejaculation. The TCA most studied for treatment of premature ejaculation is clomipramine, which may be more effective than many SSRIs for this purpose.

Clomipramine (Anafranil)

Clomipramine inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neurons. These actions are believed to be responsible for its antidepressant activity. Inhibition of serotonin probably gives rise to the SSRI-like activity that produces side effects (eg, inhibition of ejaculation).

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