Which medications in the drug class Topical anesthetic agents are used in the treatment of Premature Ejaculation?

Updated: Jan 15, 2019
  • Author: Samuel G Deem, DO; Chief Editor: Edward David Kim, MD, FACS  more...
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Topical anesthetic agents

Topical anesthetics may reduce penile sensitivity and excitability and delay ejaculation. Topical anesthetic cream is probably the lowest-risk medication that can be used for premature ejaculation; it has no adverse systemic effects, in the absence of prior hypersensitivity to the medication on the part of the patient or his partner. As a rule, there is no contraindication for combined therapy with topical anesthetics, antidepressants, and behavioral therapy.

Lidocaine 2.5% and prilocaine 2.5% (EMLA)

Lidocaine and prilocaine are amide-type local anesthetic agents. Both agents stabilize neuronal membranes by inhibiting the flow of certain ions required for the initiation and conduction of nerve impulses, thus producing local anesthesia. Lidocaine and prilocaine are applied to intact skin under an occlusive dressing, providing dermal analgesia. The effectiveness of this approach when it is applied to the penis is unproved; an occlusive dressing might also be difficult unless the penis is covered with a condom or cellophane.

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