Which medications in the drug class Beta-adrenergic Blocker are used in the treatment of Premature Ejaculation?

Updated: Jan 15, 2019
  • Author: Samuel G Deem, DO; Chief Editor: Edward David Kim, MD, FACS  more...
  • Print
Answer

Beta-adrenergic Blocker

Pindolol is a nonselective beta-adrenergic antagonist that has been shown to have 5-HT1A autoreceptor antagonist properties in the dorsal raphe nuclei. It is hypothesized that this 5-HT1A autoreceptor antagonism increases the synaptic content of 5-HT and subsequently potentiates the action of an SSRI medication. More studies are required before pindolol can be considered an ideal option for first- or second-line treatment of premature ejaculation.

Pindolol

Pindolol is a nonselective beta-adrenergic antagonist used in combination with paroxetine for premature ejaculation refractory to paroxetine alone. This is an off-label use of pindolol.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!